TLR4-Dependent Secretion by Hepatic Stellate Cells of the Neutrophil-Chemoattractant CXCL1 Mediates Liver Response to Gut Microbiota

BACKGROUND & AIMS: The gut microbiota significantly influences hepatic immunity. Little is known on the precise mechanism by which liver cells mediate recognition of gut microbes at steady state. Here we tested the hypothesis that a specific liver cell population was the sensor and we aimed at d...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bigorgne, Amélie E., John, Beena, Ebrahimkhani, Mohammad R., Shimizu-Albergine, Masami, Campbell, Jean S., Crispe, Ian N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803332/
https://ncbi.nlm.nih.gov/pubmed/27002851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151063
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