New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

BACKGROUND: Streptomyces albus J1074 produces glycosylated antibiotics paulomycin A, B and E that derive from chorismate and contain an isothiocyanate residue in form of paulic acid. Paulomycins biosynthesis pathway involves two glycosyltransferases, three acyltransferases, enzymes required for paul...

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Veröffentlicht in:Microb Cell Fact
Hauptverfasser: González, Aránzazu, Rodríguez, Miriam, Braña, Alfredo F., Méndez, Carmen, Salas, José A., Olano, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802897/
https://ncbi.nlm.nih.gov/pubmed/27001601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0452-4
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