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Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats

Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old an...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Ori, Alessandro, Toyama, Brandon H., Harris, Michael S., Bock, Thomas, Iskar, Murat, Bork, Peer, Ingolia, Nicholas T., Hetzer, Martin W., Beck, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802414/
https://ncbi.nlm.nih.gov/pubmed/27135913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2015.08.012
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