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The Amyloid Hypothesis: Is There a Role for Anti-amyloid Treatment in Late-Life Depression?

Antidepressants have modest efficacy in late-life depression, perhaps because various neurobiological processes compromise frontolimbic networks required for antidepressant response. We propose that amyloid accumulation is an etiological factor for frontolimbic compromise that predisposes to depress...

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Veröffentlicht in:Am J Geriatr Psychiatry
Hauptverfasser: Mahgoub, Nahla, Alexopoulos, George S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801691/
https://ncbi.nlm.nih.gov/pubmed/26946981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jagp.2015.12.003
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