Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors

Formation of polyploid or aneuploid cells is a pathological hallmark of malignant tumors. Cell cycle checkpoint mechanisms play a crucial role in ensuring genomic integrity during mitosis, avoiding the generation of aneuploid cells. Additionally, cancer cell DNA ploidy is subjected to extrinsic cont...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Acebes-Huerta, Andrea, Lorenzo-Herrero, Seila, Folgueras, Alicia R., Huergo-Zapico, Leticia, Lopez-Larrea, Carlos, López-Soto, Alejandro, Gonzalez, Segundo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801427/
https://ncbi.nlm.nih.gov/pubmed/27057443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1074378
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