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Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors

Deficits in long-term potentiation (LTP) at central excitatory synapses are thought to contribute to cognitive impairments in neurodevelopmental disorders associated with intellectual disability and autism. Using the methyl-CpG-binding protein 2 (Mecp2) knockout (KO) mouse model of Rett syndrome, we...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Li, Wei, Xu, Xin, Pozzo-Miller, Lucas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801299/
https://ncbi.nlm.nih.gov/pubmed/26929363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517244113
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