Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Galectin-3 (Gal-3) is a carbohydrate binding lectin, with multiple roles in inflammatory diseases and autoimmunity including its antiapoptotic effect on epithelial cells. In particular, increased expression of Gal-3 in epithelial cells is protective from apoptosis. Based on the thesis that apoptosis...

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Publicado no:Sci Rep
Main Authors: Arsenijevic, Aleksandar, Milovanovic, Marija, Milovanovic, Jelena, Stojanovic, Bojana, Zdravkovic, Natasa, Leung, Patrick S.C., Liu, Fu-Tong, Gershwin, M. Eric, Lukic, Miodrag L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800400/
https://ncbi.nlm.nih.gov/pubmed/26996208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23348
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