The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chindera, Kantaraja, Mahato, Manohar, Kumar Sharma, Ashwani, Horsley, Harry, Kloc-Muniak, Klaudia, Kamaruzzaman, Nor Fadhilah, Kumar, Satish, McFarlane, Alexander, Stach, Jem, Bentin, Thomas, Good, Liam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800398/
https://ncbi.nlm.nih.gov/pubmed/26996206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23121
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