The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Chindera, Kantaraja, Mahato, Manohar, Kumar Sharma, Ashwani, Horsley, Harry, Kloc-Muniak, Klaudia, Kamaruzzaman, Nor Fadhilah, Kumar, Satish, McFarlane, Alexander, Stach, Jem, Bentin, Thomas, Good, Liam
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800398/
https://ncbi.nlm.nih.gov/pubmed/26996206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23121
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