Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation

BACKGROUND: The B-cell receptor (BCR) has a key role in the cross-talk between chronic lymphocytic leukaemia (CLL) cells and the tissue microenvironment, which favours disease progression by promoting proliferation and drug resistance. In vitro studies on downstream signalling and functional effects...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Rombout, Ans, Lust, Sofie, Offner, Fritz, Naessens, Evelien, Verhasselt, Bruno, Philippé, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800300/
https://ncbi.nlm.nih.gov/pubmed/26924423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.35
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