Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system.
We have investigated by use of placental membranes the mechanisms through which insulin-like growth factor I (IGF-I) comes to be associated with its alpha 2 beta 2 receptor heterotetramer. Our results suggest that (i) at low ligand concentrations, the formation and disruption of IGF-I--receptor comp...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1993
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48001/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11451 |
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