An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

Transcription factor (TF) networks determine cell-type identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory network models has been hampered by a lack of comprehensive functional validation of regulatory interactions. Here, we repo...

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Udgivet i:eLife
Main Authors: Schütte, Judith, Wang, Huange, Antoniou, Stella, Jarratt, Andrew, Wilson, Nicola K, Riepsaame, Joey, Calero-Nieto, Fernando J, Moignard, Victoria, Basilico, Silvia, Kinston, Sarah J, Hannah, Rebecca L, Chan, Mun Chiang, Nürnberg, Sylvia T, Ouwehand, Willem H, Bonzanni, Nicola, de Bruijn, Marella FTR, Göttgens, Berthold
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Computational and Systems Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798972/
https://ncbi.nlm.nih.gov/pubmed/26901438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11469
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