Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleotides in segment 5 showed comparable attenuation i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gaunt, Eleanor, Wise, Helen M, Zhang, Huayu, Lee, Lian N, Atkinson, Nicky J, Nicol, Marlynne Quigg, Highton, Andrew J, Klenerman, Paul, Beard, Philippa M, Dutia, Bernadette M, Digard, Paul, Simmonds, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798949/
https://ncbi.nlm.nih.gov/pubmed/26878752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12735
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