Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture

Recombinant proteins are widely used as biopharmaceuticals, but their production by mammalian cell culture is expensive. Hence, improvement of bioprocess productivity is greatly needed. A temperature downshift (TDS) from 37°C to 28–34°C is an effective strategy to expand the productive life period o...

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Publicat a:PLoS One
Autors principals: Bedoya-López, Andrea, Estrada, Karel, Sanchez-Flores, Alejandro, Ramírez, Octavio T., Altamirano, Claudia, Segovia, Lorenzo, Miranda-Ríos, Juan, Trujillo-Roldán, Mauricio A., Valdez-Cruz, Norma A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798216/
https://ncbi.nlm.nih.gov/pubmed/26991106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151529
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