Activation of RBL-2H3 Mast Cells Is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr

Both phospholipase D1 (PLD1) and PLD2 regulate degranulation when RBL-2H3 cells are stimulated via the immunoglobulin E receptor, FcɛRI. However, the activation mechanism for PLD2 is unclear. As reported here, PLD2 but not PLD1 is phosphorylated through the Src kinases, Fyn and Fgr, and this phospho...

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Autors principals: Choi, Wahn Soo, Hiragun, Takaaki, Lee, Jun Ho, Kim, Young Mi, Kim, Hyoung-Pyo, Chahdi, Ahmed, Her, Erk, Han, Jeung Whan, Beaven, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC479740/
https://ncbi.nlm.nih.gov/pubmed/15282299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.6980-6992.2004
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