Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Glioblastoma multiforme (GBM) is the most common malignant brain tumor with a median survival time about one year. Invasion of GBM cells into normal brain is the major cause of poor prognosis and requires dynamic reorganization of the actin cytoskeleton, which includes lamellipodial protrusions, foc...

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Udgivet i:Sci Rep
Main Authors: Hayashi, Keiichiro, Michiue, Hiroyuki, Yamada, Hiroshi, Takata, Katsuyoshi, Nakayama, Hiroki, Wei, Fan-Yan, Fujimura, Atsushi, Tazawa, Hiroshi, Asai, Akira, Ogo, Naohisa, Miyachi, Hiroyuki, Nishiki, Tei-ichi, Tomizawa, Kazuhito, Takei, Kohji, Matsui, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796892/
https://ncbi.nlm.nih.gov/pubmed/26988603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23372
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