Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Glioblastoma multiforme (GBM) is the most common malignant brain tumor with a median survival time about one year. Invasion of GBM cells into normal brain is the major cause of poor prognosis and requires dynamic reorganization of the actin cytoskeleton, which includes lamellipodial protrusions, foc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hayashi, Keiichiro, Michiue, Hiroyuki, Yamada, Hiroshi, Takata, Katsuyoshi, Nakayama, Hiroki, Wei, Fan-Yan, Fujimura, Atsushi, Tazawa, Hiroshi, Asai, Akira, Ogo, Naohisa, Miyachi, Hiroyuki, Nishiki, Tei-ichi, Tomizawa, Kazuhito, Takei, Kohji, Matsui, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796892/
https://ncbi.nlm.nih.gov/pubmed/26988603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23372
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