Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells

Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic δ-cells. NST has been shown to increase glucagon secretion from primary rat pancreatic islets in low-glucose conditions. Here, we demonstrate that NST increases proglucagon message...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Regul Integr Comp Physiol
Päätekijät: Elrick, Mollisa M., Samson, Willis K., Corbett, John A., Salvatori, Alison S., Stein, Lauren M., Kolar, Grant R., Naatz, Aaron, Yosten, Gina L. C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2015
Aiheet:
Obesity, Diabetes and Energy Homeostasis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796643/
https://ncbi.nlm.nih.gov/pubmed/26561648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00369.2014
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