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Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome

Shear-dependent inhibition of lymphatic thoracic duct (TD) contractility is principally mediated by nitric oxide (NO). Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn). We tested the hypothesi...

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Dades bibliogràfiques
Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Zawieja, Scott D., Gasheva, Olga, Zawieja, David C., Muthuchamy, Mariappan
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796620/
https://ncbi.nlm.nih.gov/pubmed/26637560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00664.2015
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