Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas

High-altitude adaptation in Tibetans is influenced by introgression of a 32.7-kb haplotype from the Denisovans, an extinct branch of archaic humans, lying within the endothelial PAS domain protein 1 (EPAS1), and has also been reported in Sherpa. We genotyped 19 variants in this genomic region in 150...

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Vydáno v:Hum Genet
Hlavní autoři: Hackinger, Sophie, Kraaijenbrink, Thirsa, Xue, Yali, Mezzavilla, Massimo, Asan, van Driem, George, Jobling, Mark A., de Knijff, Peter, Tyler-Smith, Chris, Ayub, Qasim
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796332/
https://ncbi.nlm.nih.gov/pubmed/26883865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-016-1641-2
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