The complete genome sequences, unique mutational spectra and developmental potency of adult neurons revealed by cloning

Somatic mutation in neurons is linked to neurologic disease and implicated in cell type diversification. However, the origin, extent and patterns of genomic mutation in neurons remain unknown. We established a nuclear transfer method to clonally amplify the genomes of neurons from adult mice for who...

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Foilsithe in:Neuron
Main Authors: Hazen, Jennifer L., Faust, Gregory G., Rodriguez, Alberto R., Ferguson, William C., Shumilina, Svetlana, Clark, Royden A., Boland, Michael J., Martin, Greg, Chubukov, Pavel, Tsunemoto, Rachel K., Torkamani, Ali, Kupriyanov, Sergey, Hall, Ira M., Baldwin, Kristin K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795965/
https://ncbi.nlm.nih.gov/pubmed/26948891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.02.004
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