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Phenotypically Dormant and Immature Leukaemia Cells Display Increased Ribosomal Protein S6 Phosphorylation

Mechanistic/mammalian target of rapamycin (mTOR) activity drives a number of key metabolic processes including growth and protein synthesis. Inhibition of the mTOR pathway promotes cellular dormancy. Since cells from patients with acute myeloid leukaemia (AML) can be phenotypically dormant (quiescen...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Pallis, Monica, Harvey, Tamsin, Russell, Nigel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795744/
https://ncbi.nlm.nih.gov/pubmed/26985829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151480
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