Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

CYP107W1 from Streptomyces avermitilis is a cytochrome P450 enzyme involved in the biosynthesis of macrolide oligomycin A. A previous study reported that CYP107W1 regioselectively hydroxylated C12 of oligomycin C to produce oligomycin A, and the crystal structure of ligand free CYP107W1 was determin...

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Udgivet i:Mol Cells
Main Authors: Han, Songhee, Pham, Tan-Viet, Kim, Joo-Hwan, Lim, Young-Ran, Park, Hyoung-Goo, Cha, Gun-Su, Yun, Chul-Ho, Chun, Young-Jin, Kang, Lin-Woo, Kim, Donghak
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Molecular and Cellular Biology 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794603/
https://ncbi.nlm.nih.gov/pubmed/26883908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2016.2226
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