Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model

AIM: To study the interleukin-1 (IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4(-/-) (Abcb4(-/-)) mouse model. METHODS: Female and male Abcb4(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis (liv...

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Sparad:
Bibliografiska uppgifter
I publikationen:World J Hepatol
Huvudupphovsmän: Reiter, Florian P, Wimmer, Ralf, Wottke, Lena, Artmann, Renate, Nagel, Jutta M, Carranza, Manuel O, Mayr, Doris, Rust, Christian, Fickert, Peter, Trauner, Michael, Gerbes, Alexander L, Hohenester, Simon, Denk, Gerald U
Materialtyp: Artigo
Språk:Inglês
Publicerad: Baishideng Publishing Group Inc 2016
Ämnen:
Basic Study
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794530/
https://ncbi.nlm.nih.gov/pubmed/27004088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4254/wjh.v8.i8.401
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