Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy

INTRODUCTION: Inflammatory breast cancer (IBC) is an aggressive and rare cancer with a poor prognosis and a need for novel targeted therapeutic strategies. Preclinical IBC data demonstrates strong activation of the PI3K/mTOR and JAK/STAT pathways, expression of inflammatory cytokines and tumor assoc...

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Publicado no:Clin Breast Cancer
Main Authors: Jhaveri, Komal, Teplinsky, Eleonora, Silvera, Deborah, Valeta-Magara, Amanda, Arju, Rezina, Giashuddin, Shah, Sarfraz, Yasmeen, Alexander, Melissa, Darvishian, Farbod, Levine, Paul H., Hashmi, Salman, Zolfaghari, Ladan, Hoffman, Heather J., Singh, Baljit, Goldberg, Judith D., Hochman, Tsivia, Formenti, Silvia, Esteva, Francisco J., Moran, Meena S., Schneider, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794410/
https://ncbi.nlm.nih.gov/pubmed/26774497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clbc.2015.11.006
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