Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis

BACKGROUND: Optimum efficiency of the folate pathway is considered essential for adequate ovarian function. 677 C>T substitution in the 5, 10-methylene tertrahydrofolatereductase (MTHFR) gene compromises activity of the MTHFR enzyme by about 50%. The significance of correlation between 677C>T...

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Vydáno v:PLoS One
Hlavní autoři: Carlus, S. Justin, Sarkar, Saumya, Bansal, Sandeep Kumar, Singh, Vertika, Singh, Kiran, Jha, Rajesh Kumar, Sadasivam, Nirmala, Sadasivam, Sri Revathy, Gireesha, P. S., Thangaraj, Kumarasamy, Rajender, Singh
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794143/
https://ncbi.nlm.nih.gov/pubmed/26983014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151510
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