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Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species
Tat-NR2B9c, a clinical-stage stroke neuroprotectant validated in rats and primates, was recently deemed ineffective in mice. To evaluate this discrepancy, we conducted studies in mice subjected to temporary middle cerebral artery occlusion (tMCAO) for either 30 or 60 min according to the established...
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| Publicado en: | J Cereb Blood Flow Metab |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
SAGE Publications
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794097/ https://ncbi.nlm.nih.gov/pubmed/26661213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15612099 |
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