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Tissue- and species-specific differences in cytochrome c oxidase assembly induced by SURF1 defects
Mitochondrial protein SURF1 is a specific assembly factor of cytochrome c oxidase (COX), but its function is poorly understood. SURF1 gene mutations cause a severe COX deficiency manifesting as the Leigh syndrome in humans, whereas in mice SURF1(−/−) knockout leads only to a mild COX defect. We used...
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Publicado no: | Biochim Biophys Acta |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Elsevier Pub. Co
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4793088/ https://ncbi.nlm.nih.gov/pubmed/26804654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.01.007 |
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