CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal...

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Publicado en:Nat Commun
Autores principales: Bartuzi, Paulina, Billadeau, Daniel D., Favier, Robert, Rong, Shunxing, Dekker, Daphne, Fedoseienko, Alina, Fieten, Hille, Wijers, Melinde, Levels, Johannes H., Huijkman, Nicolette, Kloosterhuis, Niels, van der Molen, Henk, Brufau, Gemma, Groen, Albert K., Elliott, Alison M., Kuivenhoven, Jan Albert, Plecko, Barbara, Grangl, Gernot, McGaughran, Julie, Horton, Jay D., Burstein, Ezra, Hofker, Marten H., van de Sluis, Bart
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792963/
https://ncbi.nlm.nih.gov/pubmed/26965651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10961
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