Single-Molecule Localization Microscopy allows for the analysis of cancer metastasis-specific miRNA distribution on the nanoscale

We describe a novel approach for the detection of small non-coding RNAs in single cells by Single-Molecule Localization Microscopy (SMLM). We used a modified SMLM–setup and applied this instrument in a first proof-of-principle concept to human cancer cell lines. Our method is able to visualize singl...

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Udgivet i:Oncotarget
Main Authors: Oleksiuk, Olga, Abba, Mohammed, Tezcan, Kerem Can, Schaufler, Wladimir, Bestvater, Felix, Patil, Nitin, Birk, Udo, Hafner, Mathias, Altevogt, Peter, Cremer, Christoph, Allgayer, Heike
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792589/
https://ncbi.nlm.nih.gov/pubmed/26561203
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