Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity

In cancer immunotherapy, the use of dendritic cell (DC)-based vaccination strategies can improve overall survival, but until now durable clinical responses remain scarce. To date, DC vaccines are designed primarily to induce effective T-cell responses, ignoring the antitumor activity potential of na...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Van den Bergh, Johan, Willemen, Yannick, Lion, Eva, Van Acker, Heleen, De Reu, Hans, Anguille, Sébastien, Goossens, Herman, Berneman, Zwi, Van Tendeloo, Viggo, Smits, Evelien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper: Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792546/
https://ncbi.nlm.nih.gov/pubmed/26675759
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