SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer

FYN is a SRC family kinase (SFK) that has been shown to be up-regulated in human prostate cancer (PCa) tissues and cell lines. In this study, we observed that FYN is strongly up-regulated in human neuroendocrine PCa (NEPC) tissues and xenografts, as well as cells derived from a NEPC transgenic mouse...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gururajan, Murali, Cavassani, Karen A., Sievert, Margarit, Duan, Peng, Lichterman, Jake, Huang, Jen-Ming, Smith, Bethany, You, Sungyong, Nandana, Srinivas, Chu, Gina Chia-Yi, Mink, Sheldon, Josson, Sajni, Liu, Chunyan, Morello, Matteo, Jones, Lawrence W. M., Kim, Jayoung, Freeman, Michael R., Bhowmick, Neil, Zhau, Haiyen E., Chung, Leland W.K., Posadas, Edwin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792542/
https://ncbi.nlm.nih.gov/pubmed/26624980
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