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Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi’s sarcoma-associated herpesvirus infection

Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with B-cell lymphomas including primary effusion lymphoma and multicentric Castleman’s disease. KSHV establishes latency within B cells by modulating or mimicking the antiapoptotic Bcl-2 family of proteins to promote cell survival. Our pre...

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Publicat a:Virus Res
Autors principals: Burrer, Christine M., Foight, Glenna W., Keating, Amy E., Chan, Gary C.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792251/
https://ncbi.nlm.nih.gov/pubmed/26456186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2015.10.007
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