A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase

Osteoclast cells (OCs) are differentiated from bone marrow-derived macrophages (BMMs) by activation of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL). Activation of NADPH oxidase (Nox) isozymes is involved in RANKL-dependent OC differentiation, implicating Nox isozymes as therapeutic...

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Pubblicato in:Sci Rep
Autori principali: Joo, Jung Hee, Huh, Jeong-Eun, Lee, Jee Hyun, Park, Doo Ri, Lee, Yoonji, Lee, Seul Gee, Choi, Sun, Lee, Hwa Jeong, Song, Seong-Won, Jeong, Yongmi, Goo, Ja-Il, Choi, Yongseok, Baek, Hye Kyung, Yi, Sun Shin, Park, Soo Jin, Lee, Ji Eun, Ku, Sae Kwang, Lee, Won Jae, Lee, Kee-In, Lee, Soo Young, Bae, Yun Soo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792161/
https://ncbi.nlm.nih.gov/pubmed/26975635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22389
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