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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

[Image: see text] High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioass...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Bisson, Jonathan, McAlpine, James B., Friesen, J. Brent, Chen, Shao-Nong, Graham, James, Pauli, Guido F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2015
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791574/
https://ncbi.nlm.nih.gov/pubmed/26505758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01009
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