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Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1

The catalytic domains of most eukaryotic protein kinases are highly conserved in their primary structures. Their phosphorylation within the well-known activation T-loop, a variable region between protein kinase catalytic subdomains VII and VIII, is a common mechanism for stimulation of their phospho...

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Pubblicato in:Mol Biol Cell
Autori principali: Lai, Shenshen, Pelech, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791125/
https://ncbi.nlm.nih.gov/pubmed/26823016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-07-0527
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