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Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child

The emergence of cytotoxic T-lymphocyte (CTL) escape mutations in human immunodeficiency virus type 1 (HIV-1) proteins has been anecdotally associated with progression to AIDS, but it has been difficult to determine whether viral mutation is the cause or the result of increased viral replication. He...

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Published in:J Virol
Main Authors: Feeney, M. E., Tang, Y., Roosevelt, K. A., Leslie, A. J., McIntosh, K., Karthas, N., Walker, B. D., Goulder, P. J. R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479057/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280502/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.16.8927-8930.2004
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