Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins

Glycans normally exist as a dynamic equilibrium of several conformations. A fundamental question concerns how such molecules bind lectins despite disadvantageous entropic loss upon binding. Bisected glycan, a glycan possessing bisecting N-acetylglucosamine (GlcNAc), is potentially a good model for i...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Nagae, Masamichi, Kanagawa, Mayumi, Morita-Matsumoto, Kana, Hanashima, Shinya, Kizuka, Yasuhiko, Taniguchi, Naoyuki, Yamaguchi, Yoshiki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789653/
https://ncbi.nlm.nih.gov/pubmed/26971576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22973
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