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Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer
An essential feature of cancer is dysregulation of cell senescence and death. Renalase, a recently discovered secreted flavoprotein, provides cytoprotection against ischemic and toxic cellular injury by signaling through the PI3K-AKT and MAPK pathways. Here we show that renalase expression is increa...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4789641/ https://ncbi.nlm.nih.gov/pubmed/26972355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22996 |
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