hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells

c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL...

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Udgivet i:Sci Rep
Main Authors: Gao, Xuejuan, Feng, Junxia, He, Yujiao, Xu, Fengmei, Fan, Xiaoqin, Huang, Wensi, Xiong, Haiting, Liu, Qiuyu, Liu, Wanting, Liu, Xiaohui, Sun, Xuesong, He, Qing-Yu, Zhang, Qihao, Liu, Langxia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789638/
https://ncbi.nlm.nih.gov/pubmed/26972480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22999
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