Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

BACKGROUND: In this study, we sought to determine the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell (LSMC) function and on the development of arth...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Liang, Qianqian, Ju, Yawen, Chen, Yan, Wang, Wensheng, Li, Jinlong, Zhang, Li, Xu, Hao, Wood, Ronald W., Schwarz, Edward. M., Boyce, Brendan F., Wang, Yongjun, Xing, Lianping
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789262/
https://ncbi.nlm.nih.gov/pubmed/26970913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0963-8
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