Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

BACKGROUND: In this study, we sought to determine the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells (LECs) in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell (LSMC) function and on the development of arth...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Liang, Qianqian, Ju, Yawen, Chen, Yan, Wang, Wensheng, Li, Jinlong, Zhang, Li, Xu, Hao, Wood, Ronald W., Schwarz, Edward. M., Boyce, Brendan F., Wang, Yongjun, Xing, Lianping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789262/
https://ncbi.nlm.nih.gov/pubmed/26970913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0963-8
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