Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations

BACKGROUND: Mitotic terminally differentiated photoreceptors (PRs) are observed in early retinal degeneration (erd), an inherited canine retinal disease driven by mutations in the NDR kinase STK38L (NDR2). RESULTS: We demonstrate that a similar proliferative response, but of lower magnitude, occurs...

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Pubblicato in:BMC Genomics
Autori principali: Gardiner, Kristin L., Downs, Louise, Berta-Antalics, Agnes I., Santana, Evelyn, Aguirre, Gustavo D., Genini, Sem
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788844/
https://ncbi.nlm.nih.gov/pubmed/26969498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2477-9
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