Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

AIMS/HYPOTHESIS: Glucagon-like peptide-1 (GLP-1) is an incretin hormone derived from proglucagon, which is released from intestinal L-cells and increases insulin secretion in a glucose dependent manner. GPR119 is a lipid derivative receptor present in L-cells, believed to play a role in the detectio...

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Udgivet i:Peptides
Main Authors: Hodge, Daryl, Glass, Leslie L., Diakogiannaki, Eleftheria, Pais, Ramona, Lenaghan, Carol, Smith, David M., Wedin, Marianne, Bohlooly-Y, Mohammad, Gribble, Fiona M., Reimann, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science Inc 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788502/
https://ncbi.nlm.nih.gov/pubmed/26144594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2015.06.012
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