Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans

3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by methylation and conjugation. Alterations in CYP2D6...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Steuer, Andrea E., Schmidhauser, Corina, Tingelhoff, Eva H., Schmid, Yasmin, Rickli, Anna, Kraemer, Thomas, Liechti, Matthias E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788153/
https://ncbi.nlm.nih.gov/pubmed/26967321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150955
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