Targeting angiogenesis as a therapeutic means to reinforce osteocyte survival and prevent nonunions in the aftermath of radiotherapy

BACKGROUND: Radiotherapy (XRT) exerts detrimental collateral effects on bone tissue through mechanisms of vascular damage and impediments to osteocytes, ultimately predisposing patients to the debilitating problems of late pathologic fractures and nonunions. We posit that angiogenic therapy will rev...

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Publicat a:Head Neck
Autors principals: Donneys, Alexis, Nelson, Noah S., Page, Erin E., Deshpande, Sagar S., Felice, Peter A., Tchanque–Fossuo, Catherine N., Spiegel, Joshua P., Buchman, Steven R.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788100/
https://ncbi.nlm.nih.gov/pubmed/24801669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.23744
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