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Paradoxical suppression of small RNA activity at high Hfq concentrations due to random-order binding

Small RNAs (sRNAs) are important regulators of gene expression during bacterial stress and pathogenesis. sRNAs act by forming duplexes with mRNAs to alter their translation and degradation. In some bacteria, duplex formation is mediated by the Hfq protein, which can bind the sRNA and mRNA in each pa...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Sagawa, Shiori, Shin, Jung-Eun, Hussein, Razika, Lim, Han N.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
RNA
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787825/
https://ncbi.nlm.nih.gov/pubmed/26261213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv777
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