ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

The MRE11/RAD50/NBS1 (MRN) complex plays a central role as a sensor of DNA double strand breaks (DSB) and is responsible for the efficient activation of ataxia-telangiectasia mutated (ATM) kinase. Once activated ATM in turn phosphorylates RAD50 and NBS1, important for cell cycle control, DNA repair...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmüller, Lisa, Lavin, Martin F.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787824/
https://ncbi.nlm.nih.gov/pubmed/26240375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv754
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