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Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
When in the closed form, the substrate translocation channel of the proteasome core particle (CP) is blocked by the convergent N termini of α-subunits. To probe the role of channel gating in mammalian proteasomes, we deleted the N-terminal tail of α3; the resulting α3ΔN proteasomes are intact but hy...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786872/ https://ncbi.nlm.nih.gov/pubmed/26957043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10963 |
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