The G(q) signalling pathway inhibits brown and beige adipose tissue

Brown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the...

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Publicado en:Nat Commun
Main Authors: Klepac, Katarina, Kilić, Ana, Gnad, Thorsten, Brown, Loren M., Herrmann, Beate, Wilderman, Andrea, Balkow, Aileen, Glöde, Anja, Simon, Katharina, Lidell, Martin E., Betz, Matthias J., Enerbäck, Sven, Wess, Jürgen, Freichel, Marc, Blüher, Matthias, König, Gabi, Kostenis, Evi, Insel, Paul A., Pfeifer, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786868/
https://ncbi.nlm.nih.gov/pubmed/26955961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10895
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