IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

The immunoresponsive gene 1 (IRG1) protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species (ROS). The cytoprotective protein heme oxygenase-1 (HO-1), which generates e...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Immunol
Autori principali: Jamal Uddin, Md, Joe, Yeonsoo, Kim, Seul-Ki, Oh Jeong, Sun, Ryter, Stefan W, Pae, Hyun-Ock, Chung, Hun Taeg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786624/
https://ncbi.nlm.nih.gov/pubmed/25640654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.02
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