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Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs

Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but progressively lose this ability. This correlates with reduced damage-responsive expression of multiple genes, including th...

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Vydáno v:eLife
Hlavní autoři: Harris, Robin E, Setiawan, Linda, Saul, Josh, Hariharan, Iswar K
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786413/
https://ncbi.nlm.nih.gov/pubmed/26840050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11588
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