Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to Virulence

Herpes simplex virus type 1 causes mucocutaneous lesions, and is the leading cause of infectious blindness in the United States. Animal studies have shown that the severity of HSV-1 ocular disease is influenced by three main factors; innate immunity, host immune response and viral strain. We previou...

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Publicat a:PLoS Pathog
Autors principals: Kolb, Aaron W., Lee, Kyubin, Larsen, Inna, Craven, Mark, Brandt, Curtis R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786273/
https://ncbi.nlm.nih.gov/pubmed/26962864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005499
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